HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bell, S. D. Articles by Fraser, C. E. O. Search for Related Content PubMed PubMed Citation Articles by Bell, S. D. Articles by Fraser, C. E. O.

Experimental Trachoma in Owl Monkeys^*

Experimental trachoma in nonhuman primates has been handicapped because trachoma (as opposed to inclusion conjunctivitis) produces very mild clinical disease and minimal microbiologic changes. In a direct comparison between the Old World Taiwan monkey, Macaca cyclopis, and the New World owl monkey, Aotus trivirgatus, the latter was found to be much more susceptible. Owl monkeys manifested severe disease for a period of 2 or more weeks, while none was observed in Taiwan monkeys during the same period of time. Given identical inoculations of 2,000 EID₅₀ in the left eye and 20 EID₅₀ in the right eye, six Taiwan monkeys on the 7th day averaged 21 inclusions in the left eye and one in the right. Comparable figures for six owl monkeys were 641 and 1,396, respectively.

^* This study was supported by the Arabian American Oil Company, and by grants to the Harvard School of Public Health from the National Institutes of Health (General Research Support Grant 5-SO1-FR-5446 and the National Institute of Allergy and Infectious Diseases 5-RO1-A1-06251-02) and to the New England Regional Primate Research Center (National Institute of Health, U.S.P.H.S. Grant FR 00168-07).