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Hemodynamics of the Isolated Perfused Human Schistosomal Fibrotic Liver

With a Possible Role for a Vasoactive Factor

A method has been devised for the separation and subsequent perfusion of the liver from cadavers, the hemodynamics of four normal and six schistosomal fibrotic livers being studied. The mean arterial hepatic flow to the total hepatic flow was 36% in normal, and 66% in schistosomal, livers. The portal-vein outflow ratio (PVOR) in the normal and schistosomal livers was 38% and 72% respectively. Histamine had no effect on the hepaticarterial flow, but it increased the resistance of both hepatic and portal veins. Histamine increased the PVOR as well as the ratio of hepatic-arterial flow. We suggest that histamine can reproduce in the perfused normal human liver most of the hepatic hemodynamic changes observed in the schistosomal liver, and that histamine may play a role in the physiopathology of portal hypertension.

^* Present address: Cardiovascular Section, Cardiopulmonary Institute, Methodist Hospital of Dallas, Dallas, Texas 75222.