AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 18(2), 1969, pp. 290-296
Copyright © 1969 by The American Society of Tropical Medicine and Hygiene

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Viruses of the Venezuelan Equine Encephalomyelitis Complex

EXPERIMENTAL INFECTION OF PANAMANIAN RODENTS

N. A. Young, K. M. Johnson AND L. W. Gauld
U. S. Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Middle America Research Unit, Balboa Heights, Canal Zone

Ten spiny rats (Proechimys semispinosus) and 12 cotton rats (Sigmodon hispidus) were experimentally infected with VEE virus. Both are species that have been implicated as reservoirs of the virus in Panamá. VEE-virus titers were highest in the serum and throat on the 2nd day after inoculation. The values for Sigmodon were higher than for Proechimys. The duration of viremia, usually 4 to 5 days, was similar for the two species, but virus persisted in the throat of Sigmodon longer than in the serum and was present up to 7 days. Neutralizing antibody appeared 3 to 5 days after inoculation and preceded the disappearance of circulating virus by one or more days. Antibody titers reached a maximum by about 18 days and remained at high levels for at least 9 months.




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Copyright © 1969 by the American Society of Tropical Medicine and Hygiene.