HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Young, N. A. Articles by Johnson, K. M. Search for Related Content PubMed PubMed Citation Articles by Young, N. A. Articles by Johnson, K. M.

Viruses of the Venezuelan Equine Encephalomyelitis Complex

INFECTION AND CROSS-CHALLENGE OF RODENTS WITH VEE, MUCAMBO, AND PIXUNA VIRUSES

Experimental infections of the spiny rat, Proechimys semispinosus, with viruses of the VEE complex indicated that viremia with VEE was greatest, Mucambo viremia was less, and Pixuna viremia was least. After infection with one agent, N antibodies were usually elaborated against all three viruses of the VEE complex. After reciprocal virus challenge, viremia was not demonstrated with any of the agents. However, the N- and CF-antibody responses suggested that VEE-immunized spiny rats were protected against Mucambo and Pixuna viruses, whereas Pixuna- and Mucambo-inoculated animals were incompletely protected against infection by either of the other agents. These differences appeared to be related to quantitative variation in primary immune response, which may be a function of antigenic composition of the three viruses or of host-specific properties of the Panamanian spiny rat, or both.