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Hemagglutinin Production and Infectivity Patterns in Adult Hamsters Inoculated with Group C and Other new World Arboviruses^*

Sunthorn Srihongse AND Karl M. Johnson

Most group C arboviruses were found to induce illness and death in adult hamsters. Sick animals had high viremia as determined by the presence of serum hemagglutinins. These agglutinins had specificity comparable to that of hemagglutinins from suckling-mouse serum. Thus the adult hamster was a more economical and convenient source of virus antigen than the infant mouse. Although serum hemagglutinins were not demonstrated, subcutaneous inoculation of hamsters caused lethal infection by Eastern, Western, and Venezuelan equine encephalomyelitis viruses, as well as Chagres virus, a member of the phlebotomus-fever group, suggesting that this animal may be a valuable sentinel animal for field studies of these agents.

^* Presented at the 67th Annual Meeting of the American Society for Microbiology, New York, N. Y., 4 May 1967.

Please send requests for reprints to Dr. Sunthorn Srihongse, Gorgas Memorial Laboratory, P.O. Box 2016, Balboa Heights, Canal Zone.