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Histoplasmin Sensitivity in Mali

RESULTS OF A RECENT SKIN-TEST SURVEY WITH THE INTRADERMAL JET INJECTOR^*

Histoplasmin skin tests were applied to 1,312 primary and secondary school-children in Mali, ranging in age from 7 to 20 years. A 1:100 dilution of histoplasmin was administered intracutaneously in a dose of 0.1 ml with an automatic jet injector. Reactions were recorded 48 hours later. Of the 1,253 students who completed the study, 70 (6.0%) had reactions greater than 5 mm in diameter. Reactions greater than 5 mm were lowest in frequency for both sexes in the 7- to 10-year age group, highest for females in the 11- to 15-year age group, and for males in the 16- to 20-year age group. Infections with Histoplasma duboisii have been reported from Mali. The reactivity of persons with past or present infections of H. duboisii to standard histoplasmin antigen is highly variable. The results of this study therefore cannot be said to reflect the actual frequency and distribution of African histoplasmosis in Mali; they indicate that there is a small degree of histoplasmin sensitivity in Mali.

^* Presented at the Eighth Annual Technical Conference of the Organisation de Coordination et de Coopération pour la Lutte contre les Grandes Endémies, Bamako, 19–23 April 1968.