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Treatment of Enterobiasis with Pyrantel Pamoate

Twenty-eight children infected with Enterobius vermicularis, in a home for retarded children, were treated with a single dose of pyrantel pamoate, a new anthelmintic. Twenty-seven (96.4%) of the 28 infected children were cured. The other 41, noninfected, children in this home were similarly treated. One of these had positive post-treatment swabs; this was considered the only failure of treatment. Eighty-seven and 88 days after treatment only five of the 28 originally infected children had positive swabs, indicating a rather low incidence of reinfection. Five of the 69 children had elevated SGOT levels after treatment. All the values returned to normal 12 weeks later. Whereas side-effects in mentally retarded children are not as readily recognized as in a normal population, the only ill effects observed in this study were some looseness of stools, nausea, and vomiting. These symptoms were observed for only 1 day after treatment.