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Evaluation of Drugs for Tropical Diseases

Proceedings of a Symposium held at the Royal Society of Medicine, London, 17th February, 1967, edited by C. WILCOCKS and E. L. HARRIS ix + 95 pages, illustrated. Association of Medical Advisors in the Pharmaceutical Industry, London. 1967. 22/6d

This little book presents the proceedings of a symposium held in February 1967, under the sponsorship of the Association of Medical Advisors in the Pharmaceutical Industry (Great Britain). The text has been published in the Transactions of the Royal Society of Tropical Medicine and Hygiene; however, this publication brings it together in one volume for the first time.

The book covers four major topics: malaria, amebiasis, schistosomiasis, and leprosy. Each section deals first with methods for laboratory evaluation and in some instances a consideration of the design of new drugs, and ends with one or two papers on clinical evaluation.

The papers on malaria deal in almost handbook style with the laboratory (Peters) and clinical (Bruce-Chwatt) methods of detecting and developing antimalarial drugs. The importance of a human-volunteer establishment for Phase I studies is emphasized by Bruce-Chwatt, but he takes a dim view of the possibility of developing such a facility outside the United States.