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Am. J. Trop. Med. Hyg., 17(2), 1968, pp. 192-201
Copyright © 1968 by The American Society of Tropical Medicine and Hygiene

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The Therapeutic Effect of 4,4'-Diacetyldiamino-Diphenylsulfone (Dadds) in Leprosy

Charles C. Shepard*, Jose G. Tolentino{dagger} AND Dorothy H. McRae{ddagger}
National Communicable Disease Center, Bureau of Disease Prevention and Environmental Health, Atlanta, Georgia 30333, and Leonard Wood Memorial, Eversley Childs Sanitarium, Cebu City, Philippines

The repository sulfone 4,4'-diacetyldiaminodiphenylsulfone (DADDS) was studied for its efficacy in lepromatous leprosy. It was given in a dosage of 225 mg every 77 days to a group of 10 patients, who were matched with a group of 10 patients given oral 4,4'-diaminodiphenylsulfone (DDS, dapsone, diaphenylsulfone) in a dosage of about 100 mg per day.

Two chief criteria of therapeutic response were employed: reduction in numbers of M. leprae in nasal washings and reduction in the ratio of solidly staining M. leprae in skin smears (MI). Both criteria are thought to measure reduction in viability of the bacilli. By both measurements DADDS was as active as DDS. There were two deaths in the group receiving DADDS, but these were not thought to be connected with drug toxicity.

The blood level of "free" sulfones was usually less than 0.2 µg per ml in the patients receiving DADDS. The urinary output averaged 1.6 mg per 24 hours. It was estimated that the blood level remained several times higher than the minimum inhibitory concentration of DDS for M. leprae.


* Chief, Special Projects Unit, Virology Section, laboratory Program, National Communicable Disease Center, Atlanta, Georgia 30333.


{dagger} Chief, Clinical Research Branch, Leonard Wood Memorial, Cebu City, Philippines.


{ddagger} Public Health Technologist, Special Projects Unit, Virology Section, Laboratory Program, National Communicable Disease Center, Atlanta, Georgia 30333.






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Copyright © 1968 by the American Society of Tropical Medicine and Hygiene.