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Splenic Function in Experimental Malaria^*

Normal and splenectomized rhesus monkeys were transfused with ⁵¹chromium-labeled erythrocytes from monkeys severely infected with Plasmodium knowlesi. Radiochromium disappeared from the blood of both normal and splenectomized recipient animals at a rapid and similar rate. Parasites disappeared from the blood of normal but not splenectomized monkeys faster than did the radiochromium. This suggested that the spleen removed malaria parasites from transfused cells without destroying the erythrocytes that contained them.

^* This paper is contribution No. 241 from the Army Research Program on Malaria.

This article has been cited by other articles:

				B. Schnitzer, T. Sodeman, M. L. Mead, and P. G. Contacos Pitting Function of the Spleen in Malaria: Ultrastructural Observations Science, July 14, 1972; 177(4044): 175 - 177. [Abstract] [PDF]