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Am. J. Trop. Med. Hyg., 16(6), 1967, pp. 782-785
Copyright © 1967 by The American Society of Tropical Medicine and Hygiene

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Patterns of Viremia and Antibody Observed in Rhesus Monkeys Inoculated with Chikungunya and Other Serologically Related Group a Arboviruses*

L. N. Binn, V. R. Harrison AND R. Randall{dagger}
Division of Veterinary Medicine, The Walter Reed Army Institute of Research, Washington, D. C. 20012

The rhesus monkey is susceptible to experimental infection with chikungunya and Mayaro viruses as evidenced by a febrile reaction and high levels of circulating virus. These animals appeared refractory to infection with O'nyong-nyong virus. Infection with either Chikungunya or Mayaro virus protects these animals against infection with the heterologous virus. These results clearly show that the Asian rhesus monkey is a suitable laboratory animal for the serologic and immunologic study of selected group A arboviruses.


* A portion of this work was presented at the annual meeting of The American Society of Tropical Medicine and Hygiene, San Juan, Puerto Rico, 31 October–4 November 1966.


{dagger} Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201.






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Copyright © 1967 by the American Society of Tropical Medicine and Hygiene.