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Adsorption of Globulin to the Cuticle of Larvae and Adults of Trichinella Spiralis^*

In vitro adsorption of globulins onto the cuticle of a nematode was originally reported by Soulsby, who demonstrated this with larvae of Ascaris suum incubated in antisera from animals infected with this parasite. Coombs et al. also demonstrated that globulin adsorbed onto the cuticle of the free-living nematode Turbatrix aceti after exposure to normal human and rabbit sera. In both studies, this was demonstrated with an indicator system of human erythrocytes of Group O sensitized to human gamma globulin, then exposed to antihuman gamma globulin prepared in rabbits. The agglutinated erythrocytes adhered to the cuticle of the worm. These investigators suggested that the globulin responsible for the reaction is possibly antibody in nature.

The red-cell-adhesion reaction observed by Soulsby and Coombs was observed in the present study when larvae and adults of Trichinella spiralis were incubated in rabbit antisera and tested by the same indicator system.

Live adults and larvae were obtained from rats according to methods described elsewhere.

^* This investigation was supported by USPHS Training Grant 1 TI AI-252, National Institutes of Health, Bethesda, Maryland.