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Immunoelectrophoretic Demonstration of Specific Circulating Antigen in Animals Infected with Schistosoma Mansoni^*

With the techniques of immunoelectrophoresis, circulating antigen was demonstrable in the plasma of mice massively infected with Schistosoma mansoni. The reactant material appeared in the immunoelectropherogram as a specific anodic line, and its appearance was correlated with worm burden and duration of the infection. Experimental evidence was obtained that the antigen was not host-related. That the circulating antigen was of schistosomal origin was shown by comparative immunoelectrophoretic analyses of schistosomal homogenates and by appropriate absorption procedures.

^* Supported in part by research grant AI-00513 and training grant AI-177 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, U. S. Public Health Service.