HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stenger, R. J. Articles by Johnson, E. A. Search for Related Content PubMed PubMed Citation Articles by Stenger, R. J. Articles by Johnson, E. A.

An Electron Microscopic Study of the Liver Parenchyma and Schistosome Pigment in Murine Hepatosplenic Schistosomiasis Mansoni^*

Overt hepatosplenic schistosomiasis developed in mice after their exposure to cercariae of Schistosoma mansoni. After 8, 11, 33, and 52 weeks of infection, livers of the mice were prepared for light and electron-microscopic study. At all intervals, randomly observed and periportal parenchymal cells exhibited ultrastructural integrity. In the early phase of the disease, paragranuloma hepatocytes displayed subcellular alterations indicative of hepatocellular injury, but, at the late intervals, paragranuloma hepatocytes revealed no major ultrastructural abnormality.

These observations provided further evidence that toxic factors from adult schistosome worms do not adversely affect the hepatic parenchyma. Rather, the ultrastructural data corroborated previous evidence, indicating that the schistosome ovum is the primary factor in the pathogenesis of overt hepatosplenic schistosomiasis mansoni.

The electron-microscopic study revealed the schistosome pigment as comprised of intensely osmiophilic, very dense, ovoid and doughnut-shaped structures, which were confined in phagosomes. In this form, the pigment was observed in Kupffer's cells along the hepatic sinusoids and in the phagocytic cells of the hepatic granulomata.

^* This investigation was supported, in part, by a Public Health Service Research Grant (AM-08416) from the National Institute of Arthritis and Metabolic Diseases and by a Research Career Program Award (K3-GM-22,575) from the Institute of General Medical Sciences; and, in part, by a Rockefeller Foundation Grant (GA-MNS-6561) and Department of the Army (R&D) Contract #DA-49-193MD-2639.

This article has been cited by other articles:

				M. G. Shainheit, R. Saraceno, L. E. Bazzone, L. I. Rutitzky, and M. J. Stadecker Disruption of Interleukin-27 Signaling Results in Impaired Gamma Interferon Production but Does Not Significantly Affect Immunopathology in Murine Schistosome Infection Infect. Immun., June 1, 2007; 75(6): 3169 - 3177. [Abstract] [Full Text] [PDF]

				T.-M. CHOU, R. W. STICH, C. MARSALA, M. SCOTT, C. C. BROWN, C. A. RAWLINGS, and R. T. DAMIAN Development of a Molecular Probe to Baboon Interleukin-10 mRNA for in Situ Hybridization during Experimental Schistosomiasis Ann. N.Y. Acad. Sci., December 1, 2000; 916(1): 410 - 416. [Abstract] [Full Text] [PDF]