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A Trial of Chloroquine-Medicated Salt for Malaria Suppression in Uganda^*

S. A. Hall AND N. E. Wilks

The distribution of chloroquine-medicated salt has been proposed as an alternative method of malaria eradication where insecticidal attack is not fully effective. The small trial described here was conducted in Uganda during 1964–66 to test the use of medicated salt among a changing population at two sugar estates. Salt containing 0.38% by weight chloroquine base was issued free, and the populations' experience compared with those not receiving medicated salt.

Methods for the preparation and distribution of medicated salt are described. Satisfactory distribution led to significant reductions in crude parasite rates and reduction of morbidity to about one-third the level in nonrecipient workers, and to lower levels in women and children. Failure to achieve complete protection was attributed to administrative shortcomings, individual non-co-operation, or inadequate intake. The possibility of chloroquine resistance was excluded by use of a standard test procedure. The results of the trial were not encouraging for wider adoption, but could be justified for the situation in which it was tried.

^* This investigation received financial support from the World Health Organization and from the United States Research and Development Project, Uganda.

Ross Institute of Tropical Hygiene and Department of Preventive Medicine, Makerere University College Medical School, P.O. Box 2072, Kampala, Uganda.

Major, U.S. Army (Walter Reed Army Institute for Research), late of Makerere University College Medical School, Kampala, Uganda. Present address: c/o Col. Hugh Keegan, Preventive Medicine, MFSS, Fort Sam Houston, Texas 78234.