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Slow, Latent and Temperate Virus Infections

NINDB Monograph No. 2 Workshop and Symposium held at N.I.H., Bethesda, Maryland, 7–9 December 1964, edited by D. CARLETON GAJDUSEK, CLARENCE J. GIBBS, JR., and MICHAEL ALPERS, N.I.H., Bethesda, Maryland. xx + 489 pages, illustrated. Public Health Service Publication No. 1378. 1965. $6.75 (cloth)

Virological and immunological techniques applied to the problems of acute and chronic idiopathic disorders of the nervous system in animals and man is the subject of a symposium held in December 1964. The role of a virus or virus-gene interaction in the etiology of such diseases in humans is conjectural, but this symposium ties together what is known and presents the wide range of experimental techniques that are being used currently to study the problems. Similar degenerative diseases in animals, including scrapie and visna in sheep and Aleutian disease in minks, provide models for slow infections. Scrapie in sheep has many analogies with kuru, a familial degenerative disease of the central nervous system confined to one ethnic group, the Fore people of New Guinea. All the difficulties of working with agents that produce a progressive pathological process after a prolonged incubation period are discussed thoroughly.