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Studies on Guaroa Virus

II. Observations in Mice^*

Richard W. March AND Frank M. Hetrick

Mice at all ages tested were susceptible to Guaroa virus via the i.c. route; however, only suckling mice were susceptible following i.p. inoculation. Infected suckling-mouse material gave the highest yield of virus. Neither the sex nor the strain of mouse employed had any influence on the titers noted. A method for producing mouse ascitic fluid with high levels of hemagglutination-inhibition, complement-fixation, and neutralizing antibody to Guaroa virus is described.

^* Supported in part by Surgeon General Office Contract DA-49-193-MD-2476, Contribution No. 3839 of the Maryland Agricultural Experiment Station, Department of Veterinary Science.

Present Address: Virus & Disease Modification Section, Viral Leukemia & Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014.