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Am. J. Trop. Med. Hyg., 16(1), 1967, pp. 19-22
Copyright © 1967 by The American Society of Tropical Medicine and Hygiene

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Hepatic-Lipid Changes in Mice Infected with Plasmodium Berghei*

W. R. Wallace{dagger}, J. F. Finerty{ddagger} AND G. T. Dimopoullos
Department of Veterinary Science, Agricultural Experiment Station, and Department of Microbiology, Louisiana State University, Baton Rouge, Louisiana

Lipid analyses on hepatic tissue of mice during infection with P. berghei revealed various alterations in fatty-acid composition. Initial changes were followed by an approach toward normal late in the disease. Major changes in the concentrations of C 16:0, C 17:0, C 18:0, C 18:1, C 18:2, and C 20:4 fatty acids were noted within specific lipid classes as well as the total lipid extract.

It was of interest that almost exactly opposite changes were noted in the free fatty acids as compared with the other fractions. This is possibly a result of the pool of utilizable fatty acids derived from depot lipids being diverted to some other function, such as biosynthesis in the parasite.

A lack of change in lipase activity was shown not to be a factor in the alterations observed from esterified acids to the free fatty-acid class.


* Supported in part by research grant AI-02250 and by graduate training grant 5 T1 AI-184 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, U. S. Public Health Service.


{dagger} Present address: Department of Microbiology, Northwestern State College of Louisiana, Natchitoches, Louisiana 71457.


{ddagger} Present address: Laboratory of Germfree Animal Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014.






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Copyright © 1967 by the American Society of Tropical Medicine and Hygiene.