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The Different Effects of Antimalarial Drugs on Plasmodium Lophurae Developing Intracellularly and Extracellularly in Vitro^*

The erythrocytic stages of P. lophurae were maintained in vitro as the intracellular parasites in duck red-cell suspensions and as parasites removed from their host cells in a red-cell extract medium. Pyrimethamine, chloroquine, sulfadiazine, and quinacrine all had the expected inhibitory effect on parasites developing within their host erythrocytes. None of these drugs at the same concentrations inhibited the development of the extracellular parasites.

^* Supported in part by a grant (E-03550) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, U. S. Public Health Service, Department of Health, Education, and Welfare, Bethesda, Maryland.