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A Study Among African Schoolchildren of the Repository Antimalarial Properties of Cycloguanil Pamoate, 4,4'-Diacetyldiaminodiphenylsulfone, and a Combination of the Two Drugs

Three groups of 60 schoolchildren living in a hyperendemic zone in East Africa, where pyrimethamine-resistant Plasmodium falciparum is prevalent, were injected with a single dose of the following repository antimalarial agents:

cycloguanil pamoate, at a mean dosage of 10.8 mg (base)/kg body weight;

4,4' - diacetyldiaminodiphenylsulfone (DADDS), at a mean dosage of 6.9 mg (base)/kg body weight;

a combination of equal parts of these drugs, at a mean dosage of 12.9 mg (base)/kg body weight.

All three preparations were effective in clearing patent infections, but DADDS acted more slowly than the other preparations. Each preparation had repository action but DADDS acted for the shortest period of time. There were indications that a 1:1 combination of cycloguanil pamoate and DADDS acted longer than cycloguanil pamoate and was well tolerated. Most of the patients given the combination remained relatively parasite free for four months.

^* Now c/o Medical Research Council, London.