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Am. J. Trop. Med. Hyg., 15(6), 1966, pp. 830-832
Copyright © 1966 by The American Society of Tropical Medicine and Hygiene

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The Evaluation of Quinine Sulfate and Diaminodiphenyl Sulfone (DDS) as Suppressive Agents against Sporozoite-Induced Chesson Strain Vivax Malaria*

William Chin, Peter G. Contacos{dagger} AND G. Robert Coatney{ddagger}
Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia

The evaluation of quinine sulfate and diaminodiphenyl sulfone (DDS) as suppressants against sporozoite-induced Chesson strain Plasmodium vivax is reported. The results indicate that quinine sulfate, 7.5 grams daily, is inadequate to offer complete protection in that 3 of 4 volunteers developed patent infections. DDS, when given in daily doses of 25 mg, failed to protect 5 of 5 volunteers.


* The work reported here was carried out as part of an integrated program of the Commission of Malaria, Armed Forces Epidemiological Board, Department of Defense.


{dagger} Cytology Section, LPC, NIAID, NIH, P.O. Box 190, Chamblee, Georgia.


{ddagger} Professor of Pharmacology, Louisiana State University Medical School, New Orleans, Louisiana.






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Copyright © 1966 by the American Society of Tropical Medicine and Hygiene.