HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chin, W. Articles by King, H. K. Search for Related Content PubMed PubMed Citation Articles by Chin, W. Articles by King, H. K.

The Evaluation of Sulfonamides, Alone or in Combination with Pyrimethamine, in the Treatment of Multi-Resistant Falciparum Malaria

William Chin, Peter G. Contacos^*, G. Robert Coatney AND Herschell K. King

The evaluation of sulfadiazine, sulfamethoxypyridazine (Midicel®) and sulphorthomidine (Fanzil®) alone or combined with pyrimethamine against drug-resistant strains of Plasmodium falciparum is reported. The results indicate that (1) combination of a sulfonamide with pyrimethamine enhanced the curative effect of either one alone, (2) when combined with pyrimethamine, Midicel and Fanzil were superior to sulfadiazine, and (3) of the regimens tested, 1.0 g Fanzil as a single oral dose given together with 50 mg pyrimethamine showed the most promise for the successful treatment of the multi-drug-resistant falciparum malarias. Factors limiting the usefulness of sulfonamides as antimalarials are discussed.

^* Cytology Section, LPC, NIAID, NIH, P. O. Box 190, Chamblee, Georgia.

Present address: Department of Pharmacology, Louisiana State University, School of Medicine, New Orleans, Louisiana.