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Effect of the Antimalarial Chloroquine on the Phospholipid Metabolism of Avian Malaria and Heart Tissue^*,,

Turkey erythrocytes infected with Plasmodium fallax were incubated with C¹⁴-phosphatides, -acetate, and -fatty acids in the presence and absence of chloroquine. The C¹⁴-labeled lipids were fractionated on silicic acid columns and by paper chromatography, and the radioactivity for each fraction was assayed. The drug depressed uptake of acetate into fatty acids and phospholipids in both malaria-infected and normal erythrocytes. C¹⁴-stearic and palmitic acid incorporation into phospholipids of infected erythrocytes was increased by chloroquine while uptake of C¹⁴-oleic acid was depressed by the drug. Incorporation of C¹⁴-sodium acetate into fatty acids and phospholipids of turkey heart muscle homogenates was inhibited by the drug, and uptake of C¹⁴-stearic acid into phospholipids was stimulated by chloroquine.

^* The opinions and assertions contained herein are those of the author and are not to be construed as official or reflecting the views of the Navy Department or the Naval service at large.

From Bureau of Medicine and Surgery, Navy Department, Research Task MR 005.09.1030 Subtask .01.

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