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Levels of Oxidized and Reduced Pyridine Nucleotides in Avian Malaria (Plasmodium Lophurae)^*

Levels of reduced and oxidized pyridine nucleotides have been determined for the avian malaria parasite, Plasmodium lophurae, and its host cell the duck erythrocyte. During infection the levels of DPN, TPN and DPNH increase 1.5- to 2-fold, whereas the TPNH remains at a level similar to that of the uninfected red blood cell. The TPNH, DPNH and TPN content of erythrocyte-free P. lophurae is much like that of the normal duck erythrocyte, but the parasite DPN level is 1.5 times greater. These changes in the levels of pyridine nucleotides suggest that they may function in the regulation of metabolic pathways in malaria parasites.

^* This work was supported by a grant (AI 05226) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.