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Am. J. Trop. Med. Hyg., 15(5), 1966, pp. 725-726
Copyright © 1966 by The American Society of Tropical Medicine and Hygiene

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Further Trials with Astiban® in Schistosomiasis Mansoni: The Effect of Increased Dosage*

Mahfouz H. Zaki{dagger}, Stanley de Ramos{ddagger}, Howard B. Shookhoff§ AND Max Sterman||
The Downstate Medical Center, State University of New York and the New York City Health Department

A random sample of 19 Puerto Rican patients infected with Schistosoma mansoni were treated with a 40- to 80-mg dose of Astiban®/kg of body weight over periods ranging from 11 to 16 days. In spite of the high cure rate of 94%, the frequency and severity of the side effects do not justify the use of this massive dose in schistosomiasis chemotherapy.


* Presented at the Thirteenth Annual Meeting of the American Society of Tropical Medicine and Hygiene, New York City, November, 1964.


{dagger} Assistant Professor of Environmental Medicine and Community Health, Downstate Medical Center, State University of New York. Present address: 450 Clarkson Ave., Brooklyn, New York 11203.


{ddagger} Physician in Charge, Morrisania Tropical Disease Clinic, New York City Health Department.


§ Chief, Tropical Disease Division, New York City Health Department.


|| Physician in Charge, Washington Heights Tropical Disease Clinic, New York City Health Department.







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Copyright © 1966 by the American Society of Tropical Medicine and Hygiene.