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Studies on Sporozoite-Induced Infections of Rodent Malaria^*

III. The Course of Sporozoite-Induced Plasmodium Berghei in Different Hosts

The course of sporozoite-induced Plasmodium berghei malaria was studied in albino rats, albino mice, golden hamsters, and tree rats (Thamnomys surdaster), a natural host of this parasite. Animals were inoculated with sporozoites obtained by trituration and differential centrifugation of laboratory-bred Anopheles stephensi which 14 days previously had fed on hamsters infected with the NK 1965 strain of P. berghei.

After a uniform dose (25,000 sporozoites injected intraperitoneally) the course of infection was characteristic for each rodent species and with the exception of the mice showed little variation from experiment to experiment.

The injection of smaller inocula (10,000 and 1,000 sporozoites) not only reduced the percentage of infected animals within each species but also delayed the course of the resulting infections. This was generally refected in their longer prepatent periods, delayed onset of parasitemia, and longer survival. Young rats were shown to be the most susceptible animal to sporozoite-induced infection.

^* This investigation was conducted under the sponsorship of the Commission on Malaria of the Armed Forces Epidemiological Board, and supported in part by the Office of the Surgeon General (contribution number 61 from the Army Research Program on Malaria), and by research grant AI-02423 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Public Health Service.

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