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Studies with Dichlorvos Residual Fumigant as a Malaria Eradication Technique in Haiti

III. Toxicological Studies

William J. Stein^*, Steve Miller AND Laurice E. Fetzer, Jr.

Complaints of headache, skin rash, and diarrhea among workers who unpacked and distributed dichlorvos dispensers for malaria control led to a study of men who did the same kind of work in the next cycle of application. Mild to moderate depression of plasma cholinesterase in two groups of workers corresponded with their degree of exposure. Red cell cholinesterase was not affected. There was no recurrence of the complaints that led to the study, and no signs or symptoms of intoxication by an organic phosphorus compound were discovered.

^* Toxicology Section, Technology Branch, Communicable Disease Center, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia. Present address: 1 Clintwood Drive, Rochester, New York, 14620.

Biology/Chemistry Section, Technology Branch, Communicable Disease Center, Public Health Service, U.S. Department of Health, Education, and Welfare, Savannah, Georgia.