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Murine Hepatosplenic Schistosomiasis japonica^*

Kenneth S. Warren AND Donald E. Moore

Mice infected with an average of less than three pairs of Schistosoma japonicum worms developed signs that closely resemble clinical Schistosomiasis japonica. By 8 weeks after exposure to 14 cercariae, the animals had esophageal varices, a 70% increase in liver weight, a 100% increase in portal pressure, and a 200% increase in spleen weight. The livers contained numerous schistosome eggs (frequently in aggregates of as many as 10) surrounded by severe granulomatous reactions. Total serum protein concentration rose 20%, albumin concentration fell 70%, beta globulin concentration rose 65% and gamma globulin concentration rose 200%.

Murine Schistosomiasis japonica appears to be a more severe disease than murine schistosomiasis mansoni.

^* This investigation was conducted under the sponsorship of the Commission on Parasitic Diseases, Armed Forces Epidemiological Board, and was supported in part by the Office of the Surgeon General, Department of the Army.

Work carried out in partial fulfillment of the requirements for the M.D. degree, School of Medicine, Western Reserve University.