HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Contacos, P. G. Articles by Chin, W. Search for Related Content PubMed PubMed Citation Articles by Contacos, P. G. Articles by Chin, W.

Resistance to Cycloguanil Pamoate (CI-501) by Falciparum Malaria in West Pakistan

Peter G. Contacos^*, G. Robert Coatney, Joseph S. Lunn AND William Chin^*

The repository preparation of cycloguanil pamoate (Camolar®, CI-501) was tested therapeutically against malaria in West Pakistan. Three of the 40 villagers who were treated had recrudescences of their falciparum infections.

The parasite from one of these individuals was established in prisoner volunteers and tested for its susceptibility to various antimalarials. The results of these studies indicated that this strain of falciparum malaria was resistant to chlorguanide and pyrimethamine but susceptible to mepacrine, chloroquine, and quinine.

^* Laboratory of Parasite Chemotherapy, NIAID, NIH, Malaria Project, U. S. Penitentiary, Atlanta, Georgia.

Chief, Laboratory of Parasite Chemotherapy, NIAID, NIH, Bethesda, Maryland.

Present address: Department of Medicine, University Hospital, Syracuse, New York.