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Studies on the Antimalarial Effects of Cycloguanil Pamoate (CI-501) in Man^*

Robin D. Powell, Richard L. DeGowin AND R. Bennett Eppes

Studies on the antimalarial effects of cycloguanil pamoate (CI-501) were conducted with healthy, adult, male volunteers. Investigations were carried out in a non-malarious area and under conditions precluding reinfection. Evidence obtained confirmed findings reported previously by other workers indicating that a single intramuscular dose of CI-501 can confer protection for months against patency of sporozoite-induced infections with the Chesson strain of Plasmodium vivax. CI-501 did not exert a similar long-lasting protective effect against sporozoite-induced infections with strains of chloroquine-resistant (and chlorguanide-resistant) P. falciparum from Southeast Asia.

^* These studies were supported, in major part, by the Medical Research and Development Command, Office of the Surgeon General, Department of the Army, under contract DA-49-193-MD-2413 with the University of Chicago and, in part, by the Douglas Smith Foundation of the University of Chicago. This paper is contribution number 27 from the Army Research Program on Malaria.

Department of Medicine, University of Chicago.

Medical Corps, United States Army.