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Progress in Medical Virology

Volume 6, edited by J. L. MELNICK, Department of Virology and Epidemiology, Baylor University, College of Medicine, Houston, Texas. x + 317 pages, illustrated. Hafner Publishing Company, Inc., New York, 1964. $17.50

By far the most original article of the nine in this volume is D. L. Walker's treatment of the viral carrier state in tissue culture. Rather than merely summarizing what others have written, he starts with a formulation of a set of questions which, if answered, will contribute greatly to the unravelling of the complexities of persistent infection. He then examines relevant experimental evidence. He is particularly concerned with superinfection immunity, the nature of the resistance of the host cells, and the intracellular control of persistent infection, all of which are treated in depth. Throughout the chapter Walker gives the reader the benefit of his rigorous reasoning. Knowing his long interest in this subject, one would also appreciate some of Walker's less restrained speculations.

M. Mussgay writes most comprehensively about the growth cycle of arboviruses in vertebrate and arthropod cells. For the non-expert virologist this is a particularly useful contribution, because the data on these viruses are too widely dispersed in the literature to be easily collated.