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Glucose-6-Phosphate Dehydrogenase Deficiency and Falciparum Malaria^*

Investigations of the duration of the prepatent period and of the early clinical course of falciparum malaria (McLendon strain) were conducted with 16 non-immune American Negro men. Eight of the men were glucose-6-phosphate dehydrogenase (G6PD)-deficient and 8 were not. The investigations did not disclose evidence supporting the hypothesis that G6PD deficiency confers a biologic advantage against falciparum malaria.

^* These studies were supported, in major part, by the Medical Research and Development Command, Office of the Surgeon General, Department of the Army, under Contract DA-49-007-MD-566 with the University of Chicago, and, in part, by the Douglas Smith Foundation of the University of Chicago.

This article has been cited by other articles:

				L. Luzzatto, E. A. Usanga, and S. Reddy Glucose-6-Phosphate Dehydrogenase Deficient Red Cells: Resistance to Infection by Malarial Parasites Science, May 16, 1969; 164(3881): 839 - 842. [Abstract] [PDF]