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Experimental Chemotherapy

Volume II, edited by R. J. SCHNITZER, formerly, Chemotherapy Department, Hoffman-LaRoche, Inc., Nutley, New Jersey, and FRANK HAWKING, Division of Chemotherapy and Parasitology, National Institute for Medical Research, London, England. xvii + 614 pages, illustrated. Academic Press, New York and London. 1964. $23.00

Volume II, continuing the high standards and valuable contributions of the first volume in this series, is Part I of the Chemotherapy of Bacterial Infections. C. H. Browning describes the early history of antibacterial chemotherapy and reviews the antibacterial actions of acridines and other dyestuffs. In "The Mode of Action of Some Antibacterial Substances," H. J. Rogers deals with structure and function in bacterial and mammalian cells and the actions of sulfonamides and penicillins, along with other antibiotics that affect cell wall synthesis. Robert Knox, in "Strategy and Tactics in Antibacterial Chemotherapy," deals with the problems of specificity, the different levels of chemotherapy, and specific examples of structure-function relationships in antibacterial drugs: isoniazid, the newer penicillins. A. J. Kushner reviews "Microbial Resistance to Harsh and Destructive Environmental Conditions," particularly to heat, osmotic pressure, radiation, pH, heavy metals, classical enzyme inhibitors, surface-active agents, and disinfectants." The new and old sulfonamides are covered thoroughly in chapters by Lucien Neipp on chemotherapy and by R. E. Bagdon on pharmacology and toxicology. H. E. and M. F. Paul present an excellent review of the antibacterial and antifungal properties of the nitrofurans.