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The Antibody Response in Volunteers with Cynomolgi Malaria Infections

John E. Tobie^* AND G. Robert Coatney

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland^,

The antibody response to the B strain (six patients) and the M strain (one patient) of Plasmodium cynomolgi was studied in volunteers with sporozoite-induced infections. In all cases malarial antibody was detected after, but not before, the initial parasitemia even throughout long prepatent periods which in one individual extended 107 days. A comparison of the antibody response in patients with short or with long prepatent periods suggests that there is great similarity in respect to the abrupt rise in serum antibody levels after the initial parasitemia and to the subsequent course of antibody production.

^* Laboratory of Germfree Animal Research.

Laboratory of Parasite Chemotherapy.

Public Health Service, U. S. Department of Health, Education, and Welfare.