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Am. J. Trop. Med. Hyg., 13(5), 1964, pp. 728-733
Copyright © 1964 by The American Society of Tropical Medicine and Hygiene

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Laboratory Studies with Wild Rodents and Viruses Native to Trinidad

II. Studies with the Trinidad Caraparu-like Agent TRVL 34053-1*

A. H. Jonkers, L. Spence, W. G. Downs AND C. Brooke Worth{dagger}
University of the West Indies, Trinidad Regional Virus Laboratory, P. O. Box 164, Port of Spain, Trinidad, W. I.

Trinidad virus TRVL 34053-1, belonging in group C and closely related to Caraparu virus, was shown to circulate in the blood of naturally and experimentally infected Oryzomys laticeps velutinus. All seven experimental animals circulated virus; the maximum virus level observed in their serum was 5.8 dex LD50 for adult mice inoculated intracerebrally with 0.03 ml.

Studies with 80 experimentally infected animals, 40 Oryzomys and 40 Zygodontomys b. brevicauda, showed that hemagglutination-inhibiting (HI), complement-fixing and neutralizing antibodies persist for at least 1 year after infection with 34053-1 virus. HI antibodies derived from experimentally infected mothers of these two species persisted for about 2 months after birth and neutralizing antibodies persisted for about 1 month longer.


* The studies and observations on which this paper is based were conducted with the support and under the auspices of the Governments of Trinidad and Tobago, Jamaica, British Guiana and the Eastern Caribbean Territories, the Department of Technical Cooperation of the United Kingdom Government and The Rockefeller Foundation.


{dagger} With the technical assistance of Owen M. Olivier.






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Copyright © 1964 by the American Society of Tropical Medicine and Hygiene.