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A Study of Plasmodium Berghei in Thamnomys Surdaster, and in Other Experimental Hosts^*

The tree rat, Thamnomys surdaster, is highly susceptible to Plasmodium berghei. Ninety percent of all laboratory-bred or wild Thamnomys inoculated with one million parasitized cells succumbed to their progressive plasmodial infection within 11 to 15 days. Innate immunity to small inocula of P. berghei is encountered among individual Thamnomys. This natural immunity is quantitative in its nature and an increase in the strength of the inoculum overcomes it.

The reaction of the golden hamster towards P. berghei greatly resembles that of Thamnomys in the course of the plasmodial infection, in the individual innate quantitative immunity encountered and in the physiological ripening of the gametocytes.

^* Read before the Seventh International Congresses on Tropical Medicine and Malaria, Rio de Janeiro, Brazil, September 1963.

This investigation was conducted under the sponsorship of the Commission on Parasitic Diseases, Armed Forces Epidemiological Board, and supported in part by the Office of the Surgeon General, Department of the Army, and by research grant AI 024-23 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Public Health Service.