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Am. J. Trop. Med. Hyg., 13(4), 1964, pp. 626-628
Copyright © 1964 by The American Society of Tropical Medicine and Hygiene

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Epidemic Hemorrhagic Fever in Bolivia

II. Demonstration of Complement-Fixing Antibody in Patients' Sera with Junín Virus Antigen*

Ned H. Wiebenga, Alexis Shelokov, Clarence J. Gibbs, Jr.{dagger} AND Ronald B. Mackenzie{ddagger}
Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Tropical Virology, Bethesda, Maryland

The 1962 epidemic of a febrile disease with hemorrhagic manifestations in Bolivia was apparently due to infection by a virus related to Junín virus, the etiological agent of Argentinian hemorrhagic fever. Laboratory evidence was obtained by complement fixation tests using the Junín antigen and sera from several small population groups in and around the epidemic areas of northeast Bolivia. Distribution and concentration of complement fixing antibody were related to recent illness, and serological conversion was demonstrated in the three pairs of sera available from typical cases of the Bolivian disease.


* This material is being published simultaneously in Spanish in Rivista de Salud Pública Boliviana, IV: 19.


{dagger} Present address: National Institute of Neurological Diseases and Blindness, Collaborative and Field Research, Bethesda, Maryland.


{ddagger} Middle America Research Unit, Balboa Heights, Canal Zone.






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Copyright © 1964 by the American Society of Tropical Medicine and Hygiene.