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Am. J. Trop. Med. Hyg., 13(3), 1964, pp. 412-416
Copyright © 1964 by The American Society of Tropical Medicine and Hygiene

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Clinical Evaluation of a new Anthelmintic—Thiabendazole [2-(4'-Thiazolyl)-Benzimidazole]

D. S. Salunkhe*, B. B. Gaitonde* AND B. J. Vakil{dagger}

Thiabendazole administered to 61 patients with intestinal helminthiasis in single doses of 1.25 or 2.5 grams was found to be effective in Ascaris lumbricoides infection in a dose of 1.25 g. Its action against Ancylostoma duodenale was comparable in effectiveness to 2 g of bephenium or 3 ml of tetrachlorethylene, on the basis of mean percentage reduction in egg-count. It had no marked effect on Trichuris trichiura infection. In a dose of 2.5 g it produced giddiness and vomiting.


* Department of Pharmacology, Grant Medical College, Bombay, India.


{dagger} Asst. Hon. Physician, J. J. Group of Hospitals, Bombay, India.






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