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Fluorescent Antibody Studies in Human Malaria

I. Development of Antibodies to Plasmodium Malariae

Using the indirect fluorescent antibody method, the production and persistence of specific antibody was demonstrated in three patients inoculated with blood parasites of Plasmodium malariae. In one case a relatively high antibody level was maintained in association with persistent asymptomatic parasitemia, while in one of the others, termination of the infection resulted in a delayed, slow decline in antibody titer to a persistent lower level. Higher antibody titer appeared to be associated with the primary infection characterized by reduced parasitemia and febrile attack.

^* Present address: Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 14, Maryland.