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Effect of Chlorphenesin Carbamate (Maolate®) on a Case of Acute Arachnidism

Following a bite on the nape of the neck by a female Latrodectus mactans, a 34-year-old Negro developed classic symptoms of acute arachnidism, including diaphoresis, nausea and vomiting, apprehension, and spasm and pain of striated muscles Intravenous injections, 15 minutes apart, each of 10 ml, of 10% calcium gluconate, induced no or only minor improvement. Chlorphenesin carbamate (Maolate®) was administered in doses of two 400-mg tablets about 1 hour after the bite and again 3 hours later. Relief occurred and the patient fell asleep; he had to be awakened for each of two additional doses. It was concluded that the drug deserves further study in arachnidism, to be used as the sole therapeutic agent.