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Pathology of Schistosoma Japonicum in the Taiwanese Monkey (Macaca Cyclopis)

II. Effect of Passing the Formosan Strain through Japanese Snails

The Formosan strain of Schistosoma japonicum was passed through the Japanese snail intermediate host (Oncomelania nosophora) for four consecutive generations. Progressively rising rates of snail infection and mortality were recorded. The resultant laboratory strain of Formosan schistosome was used to infect Taiwanese monkeys. Monkeys infected with the natural Formosan strain and natural Japanese strain served as controls. Worm recovery rates were similar in the three groups. Granulomatous responses in the liver produced by the laboratory strain were compared with the large atypical granulomas of the natural Formosan strain and the conventional granulomas of the natural Japanese strain. The new Formosan strain appeared altered toward characteristics possessed by the Japanese strain.

^* Present address: Division of Pathology, U. S. Army Tropical Research Medical Laboratory, San Juan, Puerto Rico.

Address requests for reprints: Medical General Laboratory (406), U. S. Army Medical Command, Japan, APO 343, San Francisco, California.