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Am. J. Trop. Med. Hyg., 12(4), 1963, pp. 678-685
Copyright © 1963 by The American Society of Tropical Medicine and Hygiene

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Development of a Vaccine Against Colorado Tick Fever for Use in Man

Leo A. Thomas, Carl M. Eklund, Robert N. Philip AND Mary Casey*
U. S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana

A purified Colorado tick fever (CTF) vaccine has been prepared from suckling mouse brain by adsorption on calcium phosphate and elution by sodium phosphate. Elution with 0.2 M Na2HPO4 yielded antigenic preparations low in protein and allergic encephalitis-producing properties, yet high in protective potency. Potency and sensitivity tests in man and laboratory animals indicate that safe and effective vaccines against CTF may be produced by this method. Preliminary data suggest that this method of purifying CTF virus may be applicable to other similar viruses.


* Present address: Communicable Disease Center, Atlanta, Georgia.






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Copyright © 1963 by the American Society of Tropical Medicine and Hygiene.