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Am. J. Trop. Med. Hyg., 12(4), 1963, pp. 597-603
Copyright © 1963 by The American Society of Tropical Medicine and Hygiene

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Use of an Attenuated Strain of Venezuelan Equine Encephalo-Myelitis Virus for Immunization in Man*

Robert W. Mckinney, Trygve O. Berge{dagger}, W. D. Sawyer, W. D. Tigertt{ddagger} AND Dan Crozier
U. S. Army Medical Unit, Fort Detrick, Maryland

An attenuated strain of Venezuelan equine encephalomyelitis (VEE) virus has been employed for the immunization of persons at the risk of infection with virulent strains of this virus.

Systemic reactions following inoculation of either 50th or 80th passage virus occurred in approximately 40% of persons who had previously received several doses of killed vaccine. In persons who had not received the vaccine such reactions occurred in approximately 85%.

The attenuated virus elicited immunity in man against challenge with virulent unmodified virus.

A substrain was derived by plaque selection which differed from the original attenuated virus in its reduced capacity to induce untoward reactions in selected laboratory hosts and in man.

Animals inoculated with the substrain of attenuated virus resisted challenge with 109 lethal doses of four other strains of virulent VEE virus.


* Presented at Symposium on Immunization Against Arbor Virus Infections, American Society of Tropical Medicine and Hygiene, Atlanta, Georgia, 2 November 1962.

"The Principles of Laboratory Animal Care as promulgated by the National Society for Medical Research were observed in this study."


{dagger} Colonel, Medical Service Corps, United States Army. Present address: Armed Forces Institute of Pathology, Walter Reed Army Medical Center, Washington, D. C.


{ddagger} Colonel, Medical Corps, United States Army. Present address: Medical R & D Command, Office of the Surgeon General, Washington, D. C.






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Copyright © 1963 by the American Society of Tropical Medicine and Hygiene.