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Effects of Metronidazole on Trichomon as Vagin Alis in Culture and in an Experimental Host^*

Keizo Asami

Metronidazole has a potent inhibitory effect upon the multiplication of Trichomonas vaginalis in vitro. It completely inhibits growth of this organism at a concentration of 0.8 micrograms per milliliter.

Infection of the vagina of rats with T. vaginalis was induced experimentally after castration and implantation of estradiol.

A dose of 20 mg of metronidazole per kg given by mouth for 5 days resulted in complete disappearance of the organism from the vagina of a small series of rats experimentally infected. Ten mg per kg, which is similar to the dosage used in some human cases in which treatment failures have occurred, similarly resulted in a lower rate of cure in rats.

The use of rats with induced vaginal trichomoniasis seems to be valuable for screening of systemic trichomonacidal agents.

^* Read at the Tenth Annual Meeting of the American Society of Tropical Medicine and Hygiene in Washington, D. C., November 1–4, 1961.

China Medical Board Fellow, Louisiana State University School of Medicine, New Orleans, Louisiana.