HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Powell, R. D. Articles by Alving, A. S. Search for Related Content PubMed PubMed Citation Articles by Powell, R. D. Articles by Alving, A. S.

Studies on a Strain of Chloroquine-Resistant Plasmodium Falciparum from Colombia, South America^*

Robin D. Powell, George J. Brewer AND Alf S. Alving

We have confirmed that, after passage through mosquitoes, a strain of Plasmodium falciparum from Colombia, South America, is resistant to standard doses of chloroquine, hydroxychloroquine, and amodiaquine, and that radical cure of infections with this strain can be achieved by the administration of either pyrimethamine or quinine. The Colombia strain is resistant to BW 377C54, a hydroxynaphthalene derivative known to be effective against chloroquine-resistant Plasmodium berghei in mice. Preliminary investigations suggest that the concurrent weekly administration of primaquine and chloroquine, although ineffective for treatment of patent infections, may be effective in preventing patency of moderately-seeded, mosquito-induced infections of this strain.

^* These studies were supported, in major part, by the Medical Research and Development Command, Office of the Surgeon General, Department of the Army, under Contract DA-49-007-MD-566 with the University of Chicago, and, in part, by the Douglas Smith Foundation of the University of Chicago and Winthrop Laboratories, New York, N. Y.

Medical Corps, United States Army.

Department of Medicine, University of Chicago, Chicago, Illinois.

This article has been cited by other articles:

				K. H. Rieckmann Determination of the Drug Sensitivity of Plasmodium falciparum JAMA, August 2, 1971; 217(5): 573 - 578. [Abstract] [PDF]

				P. E. Thompson, A. Bayles, B. Olszewski, and J. A. Waitz Quinine-Resistant Plasmodium berghei in Mice Science, May 28, 1965; 148(3674): 1240 - 1241. [Abstract] [PDF]