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Studies on a Strain of Chloroquine-Resistant Plasmodium Falciparum from Colombia, South America^*

Robin D. Powell, George J. Brewer AND Alf S. Alving

We have confirmed that, after passage through mosquitoes, a strain of Plasmodium falciparum from Colombia, South America, is resistant to standard doses of chloroquine, hydroxychloroquine, and amodiaquine, and that radical cure of infections with this strain can be achieved by the administration of either pyrimethamine or quinine. The Colombia strain is resistant to BW 377C54, a hydroxynaphthalene derivative known to be effective against chloroquine-resistant Plasmodium berghei in mice. Preliminary investigations suggest that the concurrent weekly administration of primaquine and chloroquine, although ineffective for treatment of patent infections, may be effective in preventing patency of moderately-seeded, mosquito-induced infections of this strain.

^* These studies were supported, in major part, by the Medical Research and Development Command, Office of the Surgeon General, Department of the Army, under Contract DA-49-007-MD-566 with the University of Chicago, and, in part, by the Douglas Smith Foundation of the University of Chicago and Winthrop Laboratories, New York, N. Y.

Medical Corps, United States Army.

Department of Medicine, University of Chicago, Chicago, Illinois.

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				P. E. Thompson, A. Bayles, B. Olszewski, and J. A. Waitz Quinine-Resistant Plasmodium berghei in Mice Science, May 28, 1965; 148(3674): 1240 - 1241. [Abstract] [PDF]