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Progress in Medical Virology

edited by E. BERGER, Basel, Switzerland, and J. L. MELNICK, Houston, Texas. 302 pages, illustrated. New York. Hafner Publishing Company. 1962. $17.50

The high point of this volume is without doubt the analysis of the polyoma virus-cell relationship by A. M. Prince. In a masterfully concise manner he sets out to answer certain basic questions, clearly spelled out in the introduction, regarding the action of tumor viruses in their host cells. This is no mere collection of pertinent data. For every experiment cited, Prince outlines the reason for running it, what the experimenter thought the data showed, and where better design, more controls, or further confirmation are indicated. The review discusses infections which yield virus and those which do not, separately, and each is in turn subdivided into in vivo and in vitro sections. Each of these carry their own summary of conclusions. Practical aspects of tumor pathology appear side by side with more sophisticated views, such as the analogy between tumor induction and lysogenic conversion.It is to be hoped that the editors can now persuade Prince to discuss the Rous sarcoma virus.