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Susceptibility of Wild Rodents to Experimental Infection with Coxiella Burnetii^*

Experimental Coxiella burnetii infection in deer mice, desert wood rats, Montane meadow mice, Ord kangaroo rats, pinyon mice, and laboratory white mice was studied, employing three criteria: 28-day Phase II complement fixing antibody responses, splenomegaly, and tissue infection. Infection in guinea pigs was determined by fever response in addition to the above. All criteria gave similar ID₅₀ values with the exception of splenomegaly, which was absent in some animal species.

All tested animals were shown to be readily susceptible to intraperitoneal Q fever infection, the laboratory animals being more susceptible than the wild rodents. Disease manifestations were mild in all animals.

^* This work was supported in part by Dugway Proving Ground Contract no. DA-42-007-403-CML-427, with the University of Utah.

The experimental animals used in these studies were fed, housed and cared for in a humane manner and such care was supervised by a competent biologist (AR 70-18).