HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Box, E. D. Articles by Young, M. D. Search for Related Content PubMed PubMed Citation Articles by Box, E. D. Articles by Young, M. D.

Chloroquine-Resistant Plasmodium Falciparum from Porto Velho, Brazil

Edith D. Box^*, Quellin T. Box AND Martin D. Young

Two cases of Plasmodium falciparum infections, apparently originating in Porto Velho, Brazil, which were not eliminated by the usual curative doses of chloroquine are documented. One patient received a total of 6.675 grams chloroquine base, including four regimens varying from 0.9 to 2.1 grams each, without eradicating the parasites. She was cured subsequently by a 10-day quinine treatment. The second patient received a total of 3.675 grams chloroquine base, including two courses of 1.5 grams each, without eradicating the infection. He was cured by a 5-day treatment totaling 3.1 grams of chloroquine. This study confirms the presence of chloroquine-resistant P. falciparum in Porto Velho, Brazil, the second area in South America where chloroquine-resistant strains have been reported.

^* Department of Microbiology, University of Texas Medical Branch, Galveston, Texas.

Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas.

Department of Health, Education, and Welfare, Public Health Service, Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.