AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 12(2), 1963, pp. 236-238
Copyright © 1963 by The American Society of Tropical Medicine and Hygiene

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The Serological Reactions in a Case of Rift Valley Fever

L. N. Binn, Raymond Randall, V. R. Harrison, C. J. Gibbs, Jr.* AND C. G. Aulisio*
Department of Hazardous Operations, Walter Reed Army Institute of Research, Washington 12, D. C., and Department of Medicine, School of Medicine, University of Maryland, Baltimore 1, Maryland

The neutralizing (N), hemagglutination-inhibition (HI), and complement-fixation (CF) antibody responses following a laboratory infection with Rift Valley fever (RVF) virus in an individual have been determined. Neutralizing, HI, and CF antibodies persisted for the 18-month period of observation for which the individual was available. The advantages in economy and time required to perform HI and CF tests over the N test would be of particular value where serological cross-reactions do not occur, for example RVF.

Following inoculation of 2 cynomolgus monkeys with 106 mouse LD50 of pantropic RVF virus, the persistence of N, HI, and CF antibodies was observed for a 4-month period.


* Present address: National Institutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland.






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Copyright © 1963 by the American Society of Tropical Medicine and Hygiene.