AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 11(4), 1962, pp. 550-561
Copyright © 1962 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wisseman, C. L.
Right arrow Articles by Tamiya, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wisseman, C. L., Jr.
Right arrow Articles by Tamiya, T.

Immunological Studies with Group B Arthropod-Borne Viruses

I. Broadened Neutralizing Antibody Spectrum Induced by Strain 17D Yellow Fever Vaccine in Human Subjects Previously Infected with Japanese Encephalitis Virus*

Charles L. Wisseman, Jr. AND Benjamin H. Sweet{dagger}
Department of Microbiology, University of Maryland, School of Medicine

Masami Kitaoka AND Takeo Tamiya
National Institute of Health, Tokyo, Japan

The neutralizing antibody patterns evoked for selected Group B arthropod-borne viruses in response to inoculation with the living attenuated 17D yellow fever vaccine were compared in two groups of human subjects with the following characteristics: (1) subjects with no evidence of previous Group B arbor virus infection, and (2) subjects who had experienced primarily natural Japanese encephalitis virus infection some time prior to vaccination. The previous experience with the JE virus did not alter the pattern of appearance of YF neutralizing antibodies, either in time of appearance or in height of antibody titer. Nor did the administration of the related YF virus significantly alter the level of JE neutralizing antibodies. However, subjects with prevaccination JE antibodies developed antibodies that neutralized chiefly dengue type 1 and West Nile viruses in response to the 17D strain inoculation while subjects without prevaccination Group B arbor virus antibodies did not.


* This work was carried out under Contract No. DA-49-007-MD-660 with the Office of the Surgeon General, Department of the Army, U. S. Department of Defense under the auspices of the Commission on Immunization of the Armed Forces Epidemiological Board. A portion was presented at the Ninth Pacific Science Congress in Bangkok, Thailand, in 1957 and at the 1957 meeting of the American Society for Tropical Medicine and Hygiene.1


{dagger} Present address: Merck Institute for Research, West Point, Pennsylvania.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1962 by the American Society of Tropical Medicine and Hygiene.